Volume 9, Number 9—September 2003
Dispatch
Fluoroquinolone and Macrolide Treatment Failure in Pneumococcal Pneumonia and Selection of Multidrug-Resistant Isolates
Emilio Pérez-Trallero*†
, José M. Marimon*, Luis Iglesias*, and Julián Larruskain*
, José M. Marimon*, Luis Iglesias*, and Julián Larruskain*Table 1
In vitro antibiotic susceptibilities determined by agar dilution in Streptococcus pneumoniae isolates
| Drug | MIC (μg/mL) for each isolate/specimen collected, by date |
||||
|---|---|---|---|---|---|
| 1st isolate/sputum, 1-26-2002 | 2nd isolate/sputum, 2-8-2002 | 3rd isolate/sputum, 2-20-2002 | 4th isolate/sputum, 2-20-2002 | 5th isolate/pleural fluid, 02-26-2002 | |
| Ciprofloxacin |
2 |
32 |
16 |
16 |
16 |
| Levofloxacin |
2 |
16 |
16 |
16 |
16 |
| Moxifloxacin |
1 |
4 |
4 |
4 |
4 |
| Gemifloxacin |
0.06 |
0.5 |
0.5 |
0.5 |
0.5 |
| Erythromycin (14-m macrolide) |
0.25 |
2 |
>128 |
>128 |
>128 |
| Clarithromycin (14-m macrolide) |
0.25 |
2 |
>128 |
>128 |
>128 |
| Azithromycin (15-m macrolide) |
0.5 |
4 |
>128 |
>128 |
>128 |
| Midekamycin (16-m macrolide) |
0.5 |
4 |
128 |
64 |
16 |
| Clindamycin |
0.25 |
≤0.25 |
16 |
16 |
16 |
| Quinupristin-dalfopristin a |
1 |
32 |
>32 |
>32 |
2 |
| Telithromycin | ≤0.12 | 2 | 8 | 16 | 0.5 |
a Determined by E-test; m, membered.
