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Volume 9, Number 9—September 2003

Dispatch

Fluoroquinolone and Macrolide Treatment Failure in Pneumococcal Pneumonia and Selection of Multidrug-Resistant Isolates

Emilio Pérez-Trallero*†Comments to Author , José M. Marimon*, Luis Iglesias*, and Julián Larruskain*
Author affiliations: *Hospital Donostia, San Sebastián, Spain; †Universidad del País Vasco, San Sebastián, Spain

Main Article

Table 2

Point mutations in fluoroquinolone targets and macrolide-lincosamide-streptogramin-resistance determinants and ribosomal mutations in Streptococcus pneumoniae isolates

Location 1st isolate 2nd isolate 3rd isolate 4th isolate 5th isolate
parC
-
Ser-79
Ser-79
Ser-79
Ser-79
gyrA
Ser-81
Ser-81
Ser-81
Ser-81
Ser-81
ermA, ermB and mefA genes
-
-
-
-
-
Ribosomal protein L4
-
-
-
-
-
Amino acids insert in ribosomal protein L22
-
RTAHITa
RTAHIT
RTAHIT
-
23S rRNA gene (domain II)
-
-
-
-
-
23S rRNA gene (domain V) - - A2058G A2058G A2058G

aSequence data GenBank AY140892.

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