Volume 9, Number 9—September 2003
Dispatch
Fluoroquinolone and Macrolide Treatment Failure in Pneumococcal Pneumonia and Selection of Multidrug-Resistant Isolates
Emilio Pérez-Trallero*†
, José M. Marimon*, Luis Iglesias*, and Julián Larruskain*
, José M. Marimon*, Luis Iglesias*, and Julián Larruskain*Table 2
Point mutations in fluoroquinolone targets and macrolide-lincosamide-streptogramin-resistance determinants and ribosomal mutations in Streptococcus pneumoniae isolates
| Location | 1st isolate | 2nd isolate | 3rd isolate | 4th isolate | 5th isolate |
|---|---|---|---|---|---|
| parC |
- |
Ser-79 |
Ser-79 |
Ser-79 |
Ser-79 |
| gyrA |
Ser-81 |
Ser-81 |
Ser-81 |
Ser-81 |
Ser-81 |
| ermA, ermB and mefA genes |
- |
- |
- |
- |
- |
| Ribosomal protein L4 |
- |
- |
- |
- |
- |
| Amino acids insert in ribosomal protein L22 |
- |
RTAHITa |
RTAHIT |
RTAHIT |
- |
| 23S rRNA gene (domain II) |
- |
- |
- |
- |
- |
| 23S rRNA gene (domain V) | - | - | A2058G | A2058G | A2058G |
aSequence data GenBank AY140892.
