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Volume 14, Number 11—November 2008
Research

Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus, Rural Southwestern Alaska1

Michael Z. DavidComments to Author , Karen M. Rudolph, Thomas W. Hennessy, Susan Boyle-Vavra, and Robert S. Daum
Author affiliations: University of Chicago, Chicago, Illinois, USA (M.Z. David, S. Boyle-Vavra, R.S. Daum); Centers for Disease Control and Prevention, Anchorage, Alaska, USA (K.M. Rudolph, T.W. Hennessy);

Main Article

Table 1

Selected characteristics of MRSA isolates from southwestern Alaska, 1997, 2000, and 2004–2006*

Characteristic Retrospective collection, no. (%) Prospective collection, no. (%)
Drug susceptibility n = 36
n = 120
Ciprofloxacin 36 (100) 112 (93.3)
Clindamycin, total† 14 (39) 51 (42.5)
Single-agent testing 33 (92) 51 (42.5)
D-test negative 3/22 (14) NA
Erythromycin 11 (31) 48 (40.0)
Gentamicin 35 (97) 115 (95.8)
Rifampin 36 (100) 117 (97.5)
Vancomycin 36 (100) 120 (100)
Trimethoprim-sulfamethoxazole 35 (97) 120 (100)
Resistance to >2 non–β-lactam antimicrobial drug classes
21 (58)
69 (58)
PVL genes present n = 36
n = 42
Yes 33 (92) 42 (100)
No
3 (8)
0
SCCmec type IV
36 (100)
42 (100)
MLST CC type
CC1 22 (63) 35 (83)
ST1 20 (57) 35 (83)
ST1slv‡ 1 (3) 0
ST474 1 (3) 0
CC8 0 3 (7)
ST8 0 3 (7)
CC30 11 (32) 4 (10)
ST30 9 (26) 4 (10)
ST484 1 (3) 0
ST535 1 (3) 0
CC59 2 (6) 0
ST59 1 (3) 0
ST59slv‡ 1 (3) 0

*MRSA, methicillin-resistant Staphylococcus aureus; NA, not applicable; PVL, Panton-Valentine leukocidin; SCCmec, staphylococcal chromosomal cassette mec; MLST, multilocus sequence typing; CC, clonal complex; ST, sequence type.
†Indicates clindamycin susceptibility by single-agent testing and negative D-test results. D-tests for inducible clindamycin resistance were not indicated for any isolates from the prospective collection and were performed for 22 isolates in the retrospective collection.
‡slv, single-locus variant by MLST testing.

Main Article

1Portions of this study were presented at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, September 17–20, 2007, Chicago, IL, USA.

Page created: July 18, 2010
Page updated: July 18, 2010
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