Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 15, Number 6—June 2009
Dispatch

Oseltamivir- and Amantadine-Resistant Influenza Viruses A (H1N1)

Peter K.C. Cheng, Tommy W.C. Leung, Eric C.M. Ho, Peter C.K. Leung, Anita Y.Y. Ng, Mary Y.Y. Lai, and Wilina W.L. LimComments to Author 
Author affiliations: Centre for Health Protection, Hong Kong Special Administrative Region, People’s Republic of China

Main Article

Table

Phylogenetic analysis of HA, NA, and M2 genes of influenza viruses A (H1N1) with different drug-resistance characteristics isolated in Hong Kong, January–June 2008*

Characteristics No. isolates HA clade NA clade M2 clade Mutation
Oseltamivir resistant (n = 84)
Amantadine susceptible 81 2B† 2B 2B H274Y in NA
Amantadine resistant 1 2C† 2B 2C H274Y in NA, S31N in M2

2
2C
2C
2C
H274Y in NA, S31N in M2
Oseltamivir susceptible (n = 37)
Amantadine susceptible 20 2B 2B 2B None
Amantadine resistant 14 2C 2C 2C S31N in M2
3 2B 2B 2C S31N in M2

*HA, hemagglutinin; NA, neuraminidase; M2, matrix.
†Clade 2B or clade 2C indicates the gene specified has a nucleotide homology >99% to that of A/Brisbane/59/2007 or A/Hong Kong/2652/2006 virus, respectively.

Main Article

Page created: December 08, 2010
Page updated: December 08, 2010
Page reviewed: December 08, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external