Volume 16, Number 11—November 2010
Research
Genetic Structure of Plasmodium falciparum and Elimination of Malaria, Comoros Archipelago
Stanislas Rebaudet1, Hervé Bogreau1, Rahamatou Silaï, Jean-François Lepère, Lionel Bertaux, Bruno Pradines, Jean Delmont, Philippe Gautret, Philippe Parola, and Christophe Rogier
Table 5
Frequency of chemoresistance-associated point mutations of 5 sites studied for Plasmodium falciparum malaria, Comoros archipelago and Marseille, France*
| Locus | No. isolates (% mutations) |
||||
|---|---|---|---|---|---|
| Grande Comore | Moheli | Anjouan | Mayotte | Marseille | |
| Pfcrt | |||||
| 76T | 33 (45.5) | 33 (45.5) | 36 (13.9) | 36 (91.7) | 36 (52.8) |
| 76 T and K | 33 (9.1) | 33 (6.1) | 36 (5.6) | 36 (2.8) | 36 (0) |
| K76 (Wt) |
33 (45.5) |
33 (48.5) |
36 (80.6) |
36 (5.6) |
36 (47.2) |
| Pfdhfr | |||||
| 108N | 26 (50.0) | 19 (84.2) | 34 (38.2) | 36 (50.0) | 36 (80.6) |
| 108 N and S | 26 (15.4) | 19 (5.3) | 34 (11.8) | 36 (0) | 36 (2.8) |
| S108 (Wt) | 26 (34.6) | 19 (10.5) | 34 (50.0) | 36 (50.0) | 36 (16.7) |
| 59R | 26 (50.0) | 19 (78.9) | 34 (26.5) | 36 (44.4) | 36 (77.8) |
| 59 R and C | 26 (7.7) | 19 (10.5) | 34 (11.8) | 36 (0) | 36 (2.8) |
| C59 (Wt) | 26 (42.3) | 19 (10.5) | 34 (61.8) | 36 (55.6) | 36 (19.4) |
| 51I | 26 (38.5) | 19 (63.2) | 34 (23.5) | 36 (44.4) | 35 (65.7) |
| 51 I and N | 26 (11.5) | 19 (5.3) | 34 (2.9) | 36 (0) | 35 (2.9) |
| N51 (Wt) | 26 (50.0) | 19 (31.6) | 34 (73.5) | 36 (55.6) | 35 (31.4) |
| 108N and 59R | 26 (57.7) | 19 (89.5) | 34 (38.2) | 36 (44.4) | 36 (80.6) |
| 108N and 59R and 51I |
26 (50.0) |
19 (68.4) |
34 (26.5) |
36 (44.4) |
35 (68.6) |
| Pfdhps | |||||
| 437G | 25 (4.0) | 24 (20.8) | 31 (0) | 36 (0) | 36 (8.3) |
| 437 G and A | 25 (0) | 24 (4.2) | 31 (0) | 36 (0) | 36 (5.6) |
| A437 (Wt) | 25 (96.0) | 24 (75.0) | 31 (100.0) | 36 (100.0) | 36 (86.1) |
| 540E | 25 (0) | 24 (4.2) | 31 (0) | 36 (0) | 36 (0) |
| 540 E and K | 25 (4.0) | 24 (0) | 31 (0) | 36 (0) | 36 (0) |
| K540 (Wt) | 25 (96.0) | 24 (95.8) | 31 (100.0) | 36 (100.0) | 36 (100.0) |
| 437G and 540E | 25 (0) | 24 (0) | 31 (0) | 36 (0) | 36 (0) |
*Pfcrt, P. falciparum chloroquine resistance transporter; Pfdhpr, P. falciparum dihydrofolate reductase; Pfdhps, P. falciparum dihydropteroate synthase.
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