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Volume 9, Number 6—June 2003
Dispatch

Tick-Borne Encephalitis with Hemorrhagic Syndrome, Novosibirsk Region, Russia, 1999

Vladimir A. Ternovoi*, Gennady P. Kurzhukov†, Yuri V. Sokolov‡, Gennady Y. Ivanov‡, Vladimir A. Ivanisenko*, Alexander V. Loktev§, Robert W. Ryder¶, Sergey V. Netesov*, and Valery B. Loktev*Comments to Author 
Author affiliations: *State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk Region, Russi; †Novosibirsk State Medical Academy, Novosibirsk, Russia; ‡First Municipal Clinical Infectious Hospital of Novosibirsk, Novosibirsk, Russia; §Stanford University, Palo Alto, California, USA; ¶University of North Carolina, Chapel Hill, North Carolina, USA

Main Article

Table 2

Mutations in the amino acid sequence of protein E of hemorrhagic variants of TBEVa

Amino
acid, position TBEV,
205 Mutation in
hemorrhagic TBEV Variants of hemorrhagic TBEV Mutations in other flavivirusesb
121
Cys
Gly
Koltsovo 31

128
Thr
Ala
Koltsovo 19
Val,c Ser,d Ala,e Ilef
129
Gly
Arg
Koltsovo 31
Leud
138
Val
Ala
Koltsovo 19
Thr,c,g Gln,d Lys,e,f,h–k Glul,m
141
Val
Asp
Koltsovo 31
Val,c,d,g Glu,e,f, h,i Ser,j Thrk,l,m
170
Glu
Gly
Koltsovo 29
Gly,d Pro,e,f,h–j,m Ser,k,l
171
Arg
Lys
Koltsovo 1
Lys,c,g Ser,d,f,h,i,m Ala,e Thr,j,k Ilel
189
Ala
Ser
Koltsovo 23
Thr,g Gln,d Arg,e,f,h–1 Glym
223
Leu
Trp
Koltsovo 23

224
Ala
His
Koltsovo 23
Ser,g Thr,d Leu,e Asn,h,i Proj–m
244
Phe
Cys
Koltsovo 30

245
Gly
Val
Koltsovo 29
Glu,d–f,h,i Lysj–m
249 Ala Arg Koltsovo 30

aTBEV, tick-borne encephalitis virus.
bAlignment of protein E sequences was carried out with data from the Protein Families database (available from: URL: http://www.sanger.ac.uk/Software/Pfam/).
cPowassan virus, strain LB (Q04538).
dYellow fever virus, strain 17D (P03314).
eMurray valley encephalitis virus (P05769).
fJapanese encephalitis virus, strain CH2195 (O09754).
gKyasanur forest disease virus (SWISS-PROT Q82951).
hKunjin virus, strain MRM61C (P14335).
iSt. Louis encephalitis virus, strain MS1-7 (Q88788).
jDengue virus type 1 (O10246).
kDengue virus type 3 (P27915).
lDengue virus type 2, strain 16681 (O09234).
mDengue virus type 4 (Q88668).

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Page created: December 22, 2010
Page updated: December 22, 2010
Page reviewed: December 22, 2010
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