TY - JOUR AU - Boivin, Guy AU - Abed, Yacine AU - Boucher, François D. T1 - Human Parechovirus-3 and Neonatal Infections T2 - Emerging Infectious Disease journal PY - 2005 VL - 11 IS - 1 SP - 103 SN - 1080-6059 AB - A third serotype of human parechovirus (HPeV) has been recently isolated from stool specimens of a young Japanese child with transient paralysis. We report 3 additional cases of neonatal sepsis caused by HPeV-3 in the fall of 2001 in Canadian infants 7–27 days old. All children were hospitalized with high fever, erythematous rash, and tachypnea for a median of 5 days. The viruses isolated from nasopharyngeal aspirates grew slowly on tertiary monkey kidney cells and were successfully passaged on Vero cells. The predicted amino acid identity of the VP0-VP3-VP1 region of the three viruses was 74.6%–74.8%, 73.4%–73.6%, and 97.0%–97.1% when compared to HPeV-1, -2, and –3 prototype strains, respectively. Although different, our isolates were closely related; amino acid identity was 99.6%–100% for the latter three proteins. KW - Parechovirus-3 KW - enterovirus KW - neonatal sepsis KW - hospitalization KW - PCR KW - research KW - Canada DO - 10.3201/eid1101.040606 UR - https://wwwnc.cdc.gov/eid/article/11/1/04-0606_article ER - End of Reference