TY - JOUR AU - Monto, Arnold T1 - Vaccines and Antiviral Drugs in Pandemic Preparedness T2 - Emerging Infectious Disease journal PY - 2006 VL - 12 IS - 1 SP - 55 SN - 1080-6059 AB - While measures such as closing schools and social distancing may slow the effects of pandemic influenza, only vaccines and antiviral drugs are clearly efficacious in preventing infection or treating illness. Unless the pandemic strain closely resembles one already recognized, vaccine will not be available early. However, studies can be conducted beforehand to address questions concerning vaccine dose, frequency of inoculation, and need for adjuvants. In contrast, antiviral drugs, particularly the neuraminidase inhibitors, will be effective for treatment and available if stockpiling takes place. Special questions need to be answered if a highly lethal virus, such as influenza A (H5N1), produces the pandemic. Both vaccines and antiviral drugs will be required for a coordinated strategy. KW - Influenza KW - pandemic viruses KW - antiviral drugs KW - vaccines KW - perspective DO - 10.3201/eid1201.051068 UR - https://wwwnc.cdc.gov/eid/article/12/1/05-1068_article ER - End of Reference