TY - JOUR AU - Esper, Frank AU - Weibel, Carla AU - Ferguson, David AU - Landry, Marie AU - Kahn, Jeffrey T1 - Coronavirus HKU1 Infection in the United States T2 - Emerging Infectious Disease journal PY - 2006 VL - 12 IS - 5 SP - 775 SN - 1080-6059 AB - In 2005, a new human coronavirus, HCoV-HKU1, was identified in Hong Kong. We screened respiratory specimens collected from December 16, 2001, to December 15, 2002, from children <5 years of age who tested negative for respiratory syncytial virus, parainfluenza viruses, influenza virus, and adenovirus for HCoV-HKU1 by reverse transcription–polymerase chain reaction. Overall, 1,048 respiratory specimens from 851 children were tested, and 9 HCoV-HKU1–positive children (1%) were identified, 2 of whom had 2 positive specimens. Children who had HCoV-HKU1 infection had evidence of either upper or lower respiratory tract infection or both. Two patients had disease beyond the respiratory tract. HCoV-HKU1 was identified from December 2001 to February 2002. Sequence analyses suggest that a single strain was circulating. HCoV-HKU1 is therefore likely circulating in the United States and is associated with upper and lower respiratory tract disease. KW - Coronaviruses KW - Coronavirus HKU1 KW - HCoV-HKU1 KW - clinical features KW - respiratory infections KW - United States DO - 10.3201/eid1205.051316 UR - https://wwwnc.cdc.gov/eid/article/12/5/05-1316_article ER - End of Reference