TY - JOUR AU - Arsac, Jean-Noël AU - Andreoletti, Olivier AU - Bilheude, Jean-Marc AU - Lacroux, Caroline AU - Benestad, Sylvie L. AU - Baron, Thierry G.M. T1 - Similar Biochemical Signatures and Prion Protein Genotypes in Atypical Scrapie and Nor98 Cases, France and Norway T2 - Emerging Infectious Disease journal PY - 2007 VL - 13 IS - 1 SP - 58 SN - 1080-6059 AB - Isolates of atypical scrapie recently identified in sheep and goats in France were compared with Nor98 isolates reported in Norway. Western blot methods for characterization of the protease-resistant prion protein showed that all these isolates shared a unique biochemical signature: 5 groups of bands, including a characteristic band of apparent low molecular weight (11 kDa). This pattern could originate from the presence of 3 different protease cleavage products, including the 11 kDa most likely cleaved at both N- and C-sides of the protein. Genetic data, which strongly suggested the higher susceptibility of AHQ and AF141RQ animals in French cases, resembled earlier data from Nor98 scrapie. KW - Scrapie KW - prion KW - genotype KW - sheep KW - goat KW - Western blot KW - research KW - France KW - Norway DO - 10.3201/eid1301.060393 UR - https://wwwnc.cdc.gov/eid/article/13/1/06-0393_article ER - End of Reference