TY - JOUR AU - Fischer, Thea Kølsen AU - Nielsen, Nete Munk AU - Wohlfahrt, Jan AU - Pærregaard, Anders T1 - Incidence and Cost of Rotavirus Hospitalizations in Denmark T2 - Emerging Infectious Disease journal PY - 2007 VL - 13 IS - 6 SP - 855 SN - 1080-6059 AB - In anticipation of licensure and introduction of rotavirus vaccine into the western market, we used modeling of national hospital registry data to determine the incidence and direct medical costs of annual rotavirus-associated admissions over <11 years in Denmark. Diarrhea-associated hospitalizations coded as nonspecified viral or presumed infectious have demonstrated a marked winter peak similar to that of rotavirus-associated hospitalizations, which suggests that the registered rotavirus-coded admissions are grossly underestimated. We therefore obtained more realistic estimates by 2 different models, which indicated ≈2.4 and ≈2.5 (for children <5 years of age) and ≈4.9 and ≈5.3 (for children <2 years of age) rotavirus-associated admissions per 1,000 children per year, respectively. These admissions amount to associated direct medical costs of US $1.7–1.8 million per year. Using 2 simple models to analyze readily available hospital discharge data resulted in more consistent and reliable estimates. KW - Rotavirus KW - children KW - epidemiology KW - economic burden KW - vaccination KW - research KW - Denmark DO - 10.3201/eid1306.061432 UR - https://wwwnc.cdc.gov/eid/article/13/6/06-1432_article ER - End of Reference