TY - JOUR AU - Bruce, Michael G. AU - Deeks, Shelley L. AU - Zulz, Tammy AU - Navarro, Christine AU - Palacios, Carolina AU - Case, Cheryl AU - Hemsley, Colleen AU - Hennessy, Tom AU - Corriveau, Andre AU - Larke, Bryce AU - Sobel, Isaac AU - Lovgren, Marguerite AU - DeByle, Carolynn AU - Tsang, Raymond AU - Parkinson, Alan J. T1 - Epidemiology of Haemophilus influenzae Serotype a, North American Arctic, 2000–2005 T2 - Emerging Infectious Disease journal PY - 2008 VL - 14 IS - 1 SP - 48 SN - 1080-6059 AB - Before the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, rates of invasive H. influenzae disease among indigenous people of the North American Arctic were among the highest in the world. Routine vaccination reduced rates to low levels; however, serotype replacement with non–type b strains may result in a reemergence of invasive disease in children. We reviewed population-based data on invasive H. influenzae in Alaska and northern Canada from 2000–2005; 138 cases were reported. Among 88 typeable isolates, 42 (48%) were H. influenzae type a (Hia); 35 (83%) occurred in indigenous peoples. Among Hia patients, median age was 1.1 years; 62% were male; 1 adult died. Common clinical manifestations included meningitis, pneumonia, and septic arthritis. Overall annual incidence was 0.9 cases per 100,000 population. Incidence among indigenous children <2 years of age in Alaska and northern Canada was 21 and 102, respectively. Serotype a is now the most common H. influenzae serotype in the North American Arctic; the highest rates are among indigenous children. KW - Haemophilus influenzae KW - Hia KW - Hib KW - emerging infections KW - indigenous KW - surveillance KW - Alaska KW - Canada KW - meningitis KW - pneumonia KW - septic arthritis KW - research DO - 10.3201/eid1401.070822 UR - https://wwwnc.cdc.gov/eid/article/14/1/07-0822_article ER - End of Reference