TY - JOUR AU - Ben Amor, Yanis AU - Nemser, Bennett AU - Singh, Angad AU - Sankin, Alyssa AU - Schluger, Neil T1 - Underreported Threat of Multidrug-Resistant Tuberculosis in Africa T2 - Emerging Infectious Disease journal PY - 2008 VL - 14 IS - 9 SP - 1345 SN - 1080-6059 AB - Multidrug-resistant tuberculosis (MDR TB) in Africa may be more prevalent than previously appreciated. Factors leading to development of drug resistance need to be understood to develop appropriate control strategies for national programs. We gathered estimates of MDR TB rates for 39 of 46 countries in Africa. The relationship between MDR TB rates and independent factors was analyzed by using correlation and linear regression models. Our findings indicate that drug resistance surveys in Africa are critically needed. MDR TB rates must be assessed in countries without these surveys. In countries that have conducted a drug resistance survey, a new survey will determine evolution of drug resistance rates. We found no correlation between high MDR rates and TB incidence, HIV/TB co-infection rates, or year of introduction of rifampin. Results show that the retreatment failure rate was the most predictive indicator for MDR TB. Current category II drug regimens may increase MDR TB. KW - Tuberculosis KW - Africa KW - multidrug resistance KW - perspective DO - 10.3201/eid1409.061524 UR - https://wwwnc.cdc.gov/eid/article/14/9/06-1524_article ER - End of Reference