TY - JOUR AU - Lewis, Hannah C. AU - Mølbak, Kåre AU - Reese, Catrin AU - Aarestrup, Frank M. AU - Selchau, Mette AU - Sørum, Marit AU - Skov, Robert L. T1 - Pigs as Source of Methicillin-Resistant Staphylococcus aureus CC398 Infections in Humans, Denmark T2 - Emerging Infectious Disease journal PY - 2008 VL - 14 IS - 9 SP - 1383 SN - 1080-6059 AB - An emerging subtype of methicillin-resistant Staphylococcus aureus (MRSA), clonal complex (CC) 398, is associated with animals, particularly pigs. We conducted a matched case–control and a case–case study comparing 21 CC398 case-patients with 2 controls randomly selected from the Danish Civil Registry and 2 case-patients infected with MRSA other than CC398. On farms of case-patients, animals were examined for MRSA. Thirteen case-patients reported pig exposure. Living or working on farms with animals was an independent risk factor for CC398 in the case–control (matched odds ratio [MOR] 35.4, 95% confidence interval [CI] 2.7–469.8) and the case–case study (MOR 14.5, 95%CI 2.7–76.7). History of hospitalization was associated with an increased risk only in the case–control study (MOR 11.4, 95% CI 1.4–94.8). A total of 23 of 50 pigs on 4 of 5 farms were positive for CC398. Our results, corroborated by microbiologic testing, demonstrate that pigs are a source of CC398 in Denmark. KW - Staphylococcus aureus KW - methicillin resistance KW - community-acquired infections KW - epidemiology KW - case-control studies KW - animals KW - domestic swine (pig) KW - CC398 KW - research KW - Denmark DO - 10.3201/eid1409.071576 UR - https://wwwnc.cdc.gov/eid/article/14/9/07-1576_article ER - End of Reference