TY - JOUR AU - Bousbia, Sabri AU - Papazian, Laurent AU - Auffray, Jean-Pierre AU - Fenollar, Florence AU - Martin, Claude AU - Li, Wenjun AU - Chiche, Laurent AU - La Scola, Bernard AU - Raoult, Didier T1 - Tropheryma whipplei in Patients with Pneumonia T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 2 SP - 258 SN - 1080-6059 AB - Tropheryma whipplei is the etiologic pathogenic agent of Whipple disease (WD), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. PCR-based methods for diagnosis of WD have been developed. T. whipplei has been identified in saliva and stool samples from patients with WD and from healthy persons. T. whipplei DNA has also been found in bronchoalveolar lavage (BAL) samples of a child with pneumonia. We detected DNA of T. whipplei in 6 (3%) of 210 BAL samples collected in intensive care units by using 16S rDNA and specific quantitative PCR. We identified 4 novel genotypes of T. whipplei. In 1 case, T. whipplei was the only bacterium; in 4 others, it was associated with buccal flora. We suggest that T. whipplei should be investigated as an etiologic agent of pneumonia. KW - Tropheryma whipplei KW - Whipple disease KW - Whipple disease diagnosis KW - ventilator-associated pneumonia KW - genotyping KW - bacteria KW - research KW - France DO - 10.3201/eid1602.090610 UR - https://wwwnc.cdc.gov/eid/article/16/2/09-0610_article ER - End of Reference