TY - JOUR AU - Raoult, Didier AU - Fenollar, Florence AU - Rolain, Jean-Marc AU - Minodier, Philippe AU - Bosdure, Emmanuelle AU - Li, Wenjun AU - Garnier, Jean-Marc AU - Richet, Hervé T1 - Tropheryma whipplei in Children with Gastroenteritis T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 5 SP - 776 SN - 1080-6059 AB - Tropheryma whipplei, which causes Whipple disease, is found in human feces and may cause gastroenteritis. To show that T. whipplei causes gastroenteritis, PCRs for T. whipplei were conducted with feces from children 2–4 years of age. Western blotting was performed for samples from children with diarrhea who had positive or negative results for T. whipplei. T. whipplei was found in samples from 36 (15%) of 241 children with gastroenteritis and associated with other diarrheal pathogens in 13 (33%) of 36. No positive specimen was detected for controls of the same age (0/47; p = 0.008). Bacterial loads in case-patients were as high as those in patients with Whipple disease and significantly higher than those in adult asymptomatic carriers (p = 0.002). High incidence in patients and evidence of clonal circulation suggests that some cases of gastroenteritis are caused or exacerbated by T. whipplei, which may be co-transmitted with other intestinal pathogens. KW - Tropheryma whipplei KW - Whipple disease KW - diarrhea KW - gastroenteritis KW - bacteria KW - enteric infections KW - children KW - CME KW - research KW - France DO - 10.3201/eid1605.091801 UR - https://wwwnc.cdc.gov/eid/article/16/5/09-1801_article ER - End of Reference