TY - JOUR AU - Carr, Michael J. AU - Kajon, Adriana E. AU - Lu, Xiaoyan AU - Dunford, Linda AU - O’Reilly, Paul AU - Holder, Paul AU - De Gascun, Cillian F. AU - Coughlan, Suzie AU - Connell, Jeff AU - Erdman, Dean D. AU - Hall, William W. T1 - Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010 T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 8 SP - 1402 SN - 1080-6059 AB - Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009–July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear. KW - Adenovirus serotype 14 KW - HAdV-14p1 KW - molecular epidemiology KW - phylogenetics KW - restriction enzyme analysis KW - immunocompromised KW - immunocompetent KW - ARD KW - fatalities KW - viruses KW - Europe KW - research KW - Ireland DO - 10.3201/eid1708.101760 UR - https://wwwnc.cdc.gov/eid/article/17/8/10-1760_article ER - End of Reference