TY - JOUR AU - van der Meijden, Els AU - Kazem, Siamaque AU - Burgers, Manda M. AU - Janssens, Rene AU - Bavinck, Jan Nico Bouwes AU - de Melker, Hester AU - Feltkamp, Mariet C.W. T1 - Seroprevalence of Trichodysplasia Spinulosa–associated Polyomavirus T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 8 SP - 1355 SN - 1080-6059 AB - We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology. On the basis of knowledge regarding other polyomaviruses, we anticipated that infections with trichodysplasia spinulosa–associated polyomavirus (TSV) occur frequently and become symptomatic only in immunocompromised patients. To investigate this hypothesis, we developed and used a Luminex-based TSV viral protein 1 immunoassay, excluded cross-reactivity with phylogenetically related Merkel cell polyomavirus, and measured TSV seroreactivity. Highest reactivity was found in a TS patient. In 528 healthy persons in the Netherlands, a wide range of seroreactivities was measured and resulted in an overall TSV seroprevalence of 70% (range 10% in small children to 80% in adults). In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age. KW - trichodysplasia spinulosa KW - trichodysplasia spinulosa–associated virus KW - viruses KW - polyomavirus KW - immunoassay KW - seroprevalence KW - epidemiology KW - immunocompromised host KW - the Netherlands KW - research DO - 10.3201/eid1708.110114 UR - https://wwwnc.cdc.gov/eid/article/17/8/11-0114_article ER - End of Reference