TY - JOUR AU - Baud, David AU - Goy, Genevieve AU - Jaton, Katia AU - Osterheld, Maria-Chiara AU - Blumer, Serafin AU - Borel, Nicole AU - Vial, Yvan AU - Hohlfeld, Patrick AU - Pospischil, Andreas AU - Greub, Gilbert T1 - Role of Chlamydia trachomatis in Miscarriage T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 9 SP - 1630 SN - 1080-6059 AB - To determine the role of Chlamydia trachomatis in miscarriage, we prospectively collected serum, cervicovaginal swab specimens, and placental samples from 386 women with and without miscarriage. Prevalence of immunoglobulin G against C. trachomatis was higher in the miscarriage group than in the control group (15.2% vs. 7.3%; p = 0.018). Association between C. trachomatis–positive serologic results and miscarriage remained significant after adjustment for age, origin, education, and number of sex partners (odds ratio 2.3, 95% confidence interval 1.1–4.9). C. trachomatis DNA was more frequently amplified from products of conception or placenta from women who had a miscarriage (4%) than from controls (0.7%; p = 0.026). Immunohistochemical analysis confirmed C. trachomatis in placenta from 5 of 7 patients with positive PCR results, whereas results of immunohistochemical analysis were negative in placenta samples from all 8 negative controls tested. Associations between miscarriage and serologic/molecular evidence of C. trachomatis infection support its role in miscarriage. KW - Chlamydia trachomatis KW - abortion KW - adverse pregnancy outcome KW - placental infection KW - sexually transmitted disease KW - miscarriage KW - bacteria KW - research KW - Switzerland DO - 10.3201/eid1709.100865 UR - https://wwwnc.cdc.gov/eid/article/17/9/10-0865_article ER - End of Reference