TY - JOUR AU - Mizuta, Katsumi AU - Kuroda, Makoto AU - Kurimura, Masayuki AU - Yahata, Yoshikazu AU - Sekizuka, Tsuyoshi AU - Aoki, Yoko AU - Ikeda, Tatsuya AU - Abiko, Chieko AU - Noda, Masahiro AU - Kimura, Hirokazu AU - Mizutani, Tetsuya AU - Kato, Takeo AU - Kawanami, Toru AU - Ahiko, Tadayuki T1 - Epidemic Myalgia in Adults Associated with Human Parechovirus Type 3 Infection, Yamagata, Japan, 2008 T2 - Emerging Infectious Disease journal PY - 2012 VL - 18 IS - 11 SP - 1787 SN - 1080-6059 AB - Human parechovirus has rarely been shown to cause clinical disease in adults. During June–August 2008, a total of 22 adults sought treatment at Yonezawa City Hospital in Yamagata, Japan, for muscle pain and weakness of all limbs; most also had fever and sore throat. All patients received a clinical diagnosis of epidemic myalgia; clinical laboratory findings suggested an acute inflammatory process. Laboratory confirmation of infection with human parechovirus type 3 (HPeV3) was made for 14 patients; we isolated HPeV3 from 7 patients, detected HPeV3 genome in 11, and observed serologic confirmation of infection in 11. Although HPeV3 is typically associated with disease in young children, our results suggest that this outbreak of myalgia among adults was associated with HPeV3 infection. Clinical consideration should be given to HPeV3 not only in young children but also in adults when an outbreak occurs in the community. KW - epidemic myalgia KW - human parechovirus KW - myositis KW - Japan KW - HPeV KW - parechovirus KW - Picornaviridae KW - adults KW - children KW - myalgia KW - HPeV3 KW - viruses DO - 10.3201/eid1811.111570 UR - https://wwwnc.cdc.gov/eid/article/18/11/11-1570_article ER - End of Reference