TY - JOUR AU - Van Heirstraeten, Liesbet AU - Coenen, Samuel AU - Lammens, Christine AU - Hens, Niel AU - Goossens, Herman AU - Malhotra-Kumar, Surbhi T1 - Antimicrobial Drug Use and Macrolide-Resistant Streptococcus pyogenes, Belgium T2 - Emerging Infectious Disease journal PY - 2012 VL - 18 IS - 9 SP - 1515 SN - 1080-6059 AB - In Belgium, decreasing macrolide, lincosamide, streptogramins B, and tetracycline use during 1997–2007 correlated significantly with decreasing macrolide-resistant Streptococcus pyogenes during 1999–2009. Maintaining drug use below a critical threshold corresponded with low-level macrolide-resistant S. pyogenes and an increased number of erm(A)-harboring emm77 S. pyogenes with low fitness costs. KW - Group A streptococcus KW - antibiotic resistance KW - fitness costs KW - macrolide use KW - macrolides KW - erm(A) KW - inducible resistance KW - antimicrobial resistance KW - Belgium KW - bacteria KW - Streptococcus pyogenes DO - 10.3201/eid1809.120049 UR - https://wwwnc.cdc.gov/eid/article/18/9/12-0049_article ER - End of Reference