TY - JOUR AU - Ladhani, Shamez AU - Slack, Mary P.E. AU - Andrews, Nick AU - Waight, Pauline AU - Borrow, Ray AU - Miller, Elizabeth T1 - Invasive Pneumococcal Disease after Routine Pneumococcal Conjugate Vaccination in Children, England and Wales T2 - Emerging Infectious Disease journal PY - 2013 VL - 19 IS - 1 SP - 61 SN - 1080-6059 AB - We assessed known risk factors, clinical presentation, and outcome of invasive pneumococcal disease (IPD) in children 3–59 months of age after introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in England and Wales. During September 2006–March 2010, a total of 1,342 IPD episodes occurred in 1,332 children; 14.9% (198/1,332) had comorbidities. Compared with IPD caused by PCV7 serotypes (44/248; 17.7%), comorbidities were less common for the extra 3 serotypes in the 10-valent vaccine (15/299; 5.0%) but similar to the 3 additional PCV13 serotypes (45/336; 13.4%) and increased for the 11 extra serotypes in 23-valent polysaccharide vaccine (PPV23) (39/186; 21.0%) and non-PPV23 serotypes (38/138; 27.5%). Fifty-two (3.9%) cases resulted from PCV7 failure; 9 (0.7%) case-patients had recurrent IPD. Case-fatality rate was 4.4% (58/1,332) but higher for meningitis (11.0%) and children with comorbidities (9.1%). Thus, comorbidities were more prevalent in children with IPD caused by non-PCV13 serotypes and were associated with increased case fatality. KW - Invasive pneumococcal disease KW - risk factors KW - serotypes KW - meningitis KW - outcome KW - vaccination KW - bacteria KW - England KW - Wales KW - children DO - 10.3201/eid1901.120741 UR - https://wwwnc.cdc.gov/eid/article/19/1/12-0741_article ER - End of Reference