TY - JOUR AU - Peters, Philip AU - Brooks, John AU - McAllister, Sigrid AU - Limbago, Brandi AU - Lowery, H. Ken AU - Fosheim, Gregory AU - Guest, Jodie AU - Gorwitz, Rachel AU - Bethea, Monique AU - Hageman, Jeffrey AU - Mindley, Rondeen AU - McDougal, Linda AU - Rimland, David T1 - Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults T2 - Emerging Infectious Disease journal PY - 2013 VL - 19 IS - 4 SP - 623 SN - 1080-6059 AB - Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007–2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at enrollment and after 6 and 12 months. MRSA colonization was detected in 13%–15% of HIV-infected participants (n = 600, 98% male) at baseline, 6 months, and 12 months. MRSA colonization was detected in the nares only (41%), groin only (21%), and at both sites (38%). Over a median of 2.1 years of follow-up, 29 MRSA clinical infections occurred in 25 participants. In multivariate analysis, MRSA clinical infection was significantly associated with MRSA colonization of the groin (adjusted risk ratio 4.8) and a history of MRSA infection (adjusted risk ratio 3.1). MRSA prevention strategies that can effectively prevent or eliminate groin colonization are likely necessary to reduce clinical infections in this population. KW - HIV KW - methicillin-resistant Staphylococcus aureus KW - colonization KW - viruses KW - bacteria KW - Georgia KW - MRSA KW - staphylococci DO - 10.3201/eid1904.121353 UR - https://wwwnc.cdc.gov/eid/article/19/4/12-1353_article ER - End of Reference