TY - JOUR AU - Levin, Bruce R. T1 - The Evolution and Maintenance of Virulence in Microparasites T2 - Emerging Infectious Disease journal PY - 1996 VL - 2 IS - 2 SP - 93 SN - 1080-6059 AB - In recent years, population and evolutionary biologists have questioned the traditional view that parasite-mediated morbidity and mortality—virulence—is a primitive character and an artifact of recent associations between parasites and their hosts. A number of hypotheses have been proposed that favor virulence and suggest that it will be maintained by natural selection. According to some of these hypotheses, the pathogenicity of HIV, Vibrio cholerae, Mycobacterium tuberculosis, the Shigella, as well as Plasmodium falciparum, and many other microparasites, are not only maintained by natural selection, but their virulence increases or decreases as an evolutionary response to changes in environmental conditions or the density and/or behavior of the human population. Other hypotheses propose that the virulence of microparasites is not directly favored by natural selection; rather, microparasite-mediated morbidity and mortality are either coincidental to parasite-expressed characters (virulence determinants that evolved for other functions) or the product of short-sighted evolution in infected hosts. These hypotheses for the evolution and maintenance of microparasite virulence are critically reviewed, and suggestions are made for testing them experimentally. KW - United States DO - 10.3201/eid0202.960203 UR - https://wwwnc.cdc.gov/eid/article/2/2/96-0203_article ER - End of Reference