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Volume 2, Number 2—April 1996
Dispatch

Invasive Penicillin-Resistant Pneumococcal Infections:
A Prevalence and Historical Cohort Study

Crystal B. Kronenberger*, Richard E. Hoffman†, Dennis C. Lezotte*, and William M. Marine*
Author affiliations: *Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA; †Colorado Department of Public Health and Environment, Denver, Colorado, USA

Main Article

Table

Demographic and clinical characteristics of patients with invasive penicillin-resistant S. pneumoniae (PRSP) and penicillin-sensitive S. pneumoniae (PSSP) infections

PRSP;
n = 29 (%) PSSP;
n = 180 (%) Odds ratio
(95% confidence interval)
Demographic characteristics
Age, years
        < 5
11 (38)
39 (22)
1.9 (0.4-9.1)
        5-64
8 (28)
93 (52)
Reference
        > 64
10 (34)
48 (27)
1.9 (0.5-7.1)
Sex
        Male
12 (41)
104 (58)
Reference
        Female
17 (59)
76 (42)
1.8 (0.6-5.4)
Racea
        White
16 (55)
100 (56)
Reference
        Nonwhite
11 (38)
68 (38)
1.4 (0.5-3.9)
Clinical characteristics
Site of infection
        Blood
26 (90)
171 (95)
Reference
        CSF
3 (10)
9 (5)
0.8 (0.1-5.1)
    Underlying medical condition
14 (48)
108 (60)
1.0 (0.3-3.2)
    Antibiotic useb
14 (52)
56 (39)
2.5 (0.9-7.1)
    No history of penicillin allergyc
26 (90)
163 (91)
0.7 (0.1-3.4)
    Previous hospitalizationd
5 (19)
33 (23)
0.3 (0.1-1.5)
Day-care attendance
        Patients < 11 yearse
5 (50)
19 (50)
1.1 (0.4-2.7)
        Household member(s)f
7 (26)
10 (7)
8.1 (2.2-30.7)
Residence in a long-term care facility
    (patients > 64 years)g
2 (20)
13 (27)
0.7 (0.1-3.6)
    Hospital-acquired infection
1 (3)
8 (4)
0.4 (0.04-4.9)
Outcome
        Survived
25 (86)
156 (87)
Reference
        Died 4 (14) 24 (13) 1.6 (0.4-6.3)

a Missing information on 2 PRSP and 12 PSSP patients.
b Includes patients who had taken an antibiotic in the 3 months before illness; missing information on 2 PRSP and 36 PSSP patients.
c Missing information on 1 PSSP patient.
d Patients who were hospitalized in the 3 months before illness; missing information on 2 PRSP and 34 PSSP patients.
e Children < 11 years of age who attended day care in the 3 months before illness; children < 11 years of age, N = 56 (PRSP = 12, PSSP = 44); missing information on 2 PRSP and 6 PSSP patients.
f Patients with at least 1 child < 11 years of age (excluding the patient) in the household who attended day care in the 3 months before illness; missing information on 2 PRSP and 39 PSSP patients.
g Adults > 64 years of age who resided in a LTC facility in the 3 months before illness; adults > 64 years of age, N = 58 (PRSP = 10, PSSP = 48).

Main Article

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