TY - JOUR AU - Blouin, Yann AU - Cazajous, Géraldine AU - Dehan, Céline AU - Soler, Charles AU - Vong, Rithy AU - Hassan, Mohamed Osman AU - Hauck, Yolande AU - Boulais, Christian AU - Andriamanantena, Dina AU - Martinaud, Christophe AU - Martin, Émilie AU - Pourcel, Christine AU - Vergnaud, Gilles T1 - Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti T2 - Emerging Infectious Disease journal PY - 2014 VL - 20 IS - 1 SP - 21 SN - 1080-6059 AB - “Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important. KW - Mycobacterium KW - tuberculosis KW - lymph node tuberculosis KW - Mycobacterium canettii KW - disease outbreaks KW - Djibouti KW - tuberculosis and other mycobacteria DO - 10.3201/eid2001.130652 UR - https://wwwnc.cdc.gov/eid/article/20/1/13-0652_article ER - End of Reference