TY - JOUR AU - Steinau, Martin AU - Saraiya, Mona AU - Goodman, Marc AU - Peters, Edward AU - Watson, Meg AU - Cleveland, Jennifer AU - Lynch, Charles AU - Wilkinson, Edward AU - Hernandez, Brenda AU - Copeland, Glen AU - Saber, Maria AU - Hopenhayn, Claudia AU - Huang, Youjie AU - Cozen, Wendy AU - Lyu, Christopher AU - Unger, Elizabeth T1 - Human Papillomavirus Prevalence in Oropharyngeal Cancer before Vaccine Introduction, United States T2 - Emerging Infectious Disease journal PY - 2014 VL - 20 IS - 5 SP - 822 SN - 1080-6059 AB - We conducted a study to determine prevalence of HPV types in oropharyngeal cancers in the United States and establish a prevaccine baseline for monitoring the impact of vaccination. HPV DNA was extracted from tumor tissue samples from patients in whom cancer was diagnosed during 1995–2005. The samples were obtained from cancer registries and Residual Tissue Repository Program sites in the United States. HPV was detected and typed by using PCR reverse line blot assays. Among 557 invasive oropharyngeal squamous cell carcinomas, 72% were positive for HPV and 62% for vaccine types HPV16 or 18. Prevalence of HPV-16/18 was lower in women (53%) than in men (66%), and lower in non-Hispanic Black patients (31%) than in other racial/ethnic groups (68%–80%). Results indicate that vaccines could prevent most oropharyngeal cancers in the United States, but their effect may vary by demographic variables. KW - oropharynx KW - oropharyngeal KW - cancer KW - HPV typing KW - human papillomavirus KW - archived tissue KW - viruses KW - United States DO - 10.3201/eid2005.131311 UR - https://wwwnc.cdc.gov/eid/article/20/5/13-1311_article ER - End of Reference