TY - JOUR AU - Bitar, Dounia AU - Lortholary, Olivier AU - Le Strat, Yann AU - Nicolau, Javier AU - Coignard, Bruno AU - Tattevin, Pierre AU - Che, Didier AU - Dromer, Françoise T1 - Population-Based Analysis of Invasive Fungal Infections, France, 2001–2010 T2 - Emerging Infectious Disease journal PY - 2014 VL - 20 IS - 7 SP - 1163 SN - 1080-6059 AB - To determine the epidemiology and trends of invasive fungal infections (IFIs) in France, we analyzed incidence, risk factors, and in-hospital death rates related to the most frequent IFIs registered in the national hospital discharge database during 2001–2010. The identified 35,876 IFI cases included candidemia (43.4%), Pneumocystis jirovecii pneumonia (26.1%), invasive aspergillosis (IA, 23.9%), cryptococcosis (5.2%), and mucormycosis (1.5%). The overall incidence was 5.9/100,000 cases/year and the mortality rate was 27.6%; both increased over the period (+1.5%, +2.9%/year, respectively). Incidences substantially increased for candidemia, IA, and mucormycosis. Pneumocystis jirovecii pneumonia incidence decreased among AIDS patients (−14.3%/year) but increased in non-HIV–infected patients (+13.3%/year). Candidemia and IA incidence was increased among patients with hematologic malignancies (>+4%/year) and those with chronic renal failure (>+10%/year). In-hospital deaths substantially increased in some groups, e.g., in those with hematologic malignancies. IFIs occur among a broad spectrum of non–HIV-infected patients and should be a major public health priority. KW - Invasive mycosis KW - candidemia KW - Pneumocystis jirovecii KW - aspergillosis KW - cryptococcosis KW - mucormycosis KW - France DO - 10.3201/eid2007.140087 UR - https://wwwnc.cdc.gov/eid/article/20/7/14-0087_article ER - End of Reference