TY - JOUR AU - Latus, Joerg AU - Schwab, Matthias AU - Tacconelli, Evelina AU - Pieper, Friedrich-Michael AU - Wegener, Daniel AU - Dippon, Juergen AU - Müller, Simon AU - Zakim, David AU - Segerer, Stephan AU - Kitterer, Daniel AU - Priwitzer, Martin AU - Mezger, Barbara AU - Walter-Frank, Birgit AU - Corea, Angela AU - Wiedenmann, Albrecht AU - Brockmann, Stefan AU - Pöhlmann, Christoph AU - Alscher, M. Dominik AU - Braun, Niko T1 - Clinical Course and Long-Term Outcome of Hantavirus-Associated Nephropathia Epidemica, Germany T2 - Emerging Infectious Disease journal PY - 2015 VL - 21 IS - 1 SP - 76 SN - 1080-6059 AB - Human infection with Puumala virus (PUUV), the most common hantavirus in Central Europe, causes nephropathia epidemica (NE), a disease characterized by acute kidney injury and thrombocytopenia. To determine the clinical phenotype of hantavirus-infected patients and their long-term outcome and humoral immunity to PUUV, we conducted a cross-sectional prospective survey of 456 patients in Germany with clinically and serologically confirmed hantavirus-associated NE during 2001–2012. Prominent clinical findings during acute NE were fever and back/limb pain, and 88% of the patients had acute kidney injury. At follow-up (7–35 mo), all patients had detectable hantavirus-specific IgG; 8.5% had persistent IgM; 25% had hematuria; 23% had hypertension (new diagnosis for 67%); and 7% had proteinuria. NE-associated hypertension and proteinuria do not appear to have long-term consequences, but NE-associated hematuria may. All patients in this study had hantavirus-specific IgG up to years after the infection. KW - Hantavirus KW - PUUV KW - Puumala virus KW - nephropathia epidemica KW - epidemic nephropathy KW - long-term outcome KW - hematuria KW - hypertension KW - proteinuria KW - viruses KW - acute kidney injury KW - Germany DO - 10.3201/eid2101.140861 UR - https://wwwnc.cdc.gov/eid/article/21/1/14-0861_article ER - End of Reference