TY - JOUR AU - Ao, Trong AU - Feasey, Nicholas AU - Gordon, Melita AU - Keddy, Karen AU - Angulo, Frederick AU - Crump, John T1 - Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010 T2 - Emerging Infectious Disease journal PY - 2015 VL - 21 IS - 6 SP - 941 SN - 1080-6059 AB - Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected and malnourished children are at increased risk for the disease. We conducted a systematic literature review to obtain age group–specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1–6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30–94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, had the highest incidence (227 cases [range 152–341] per 100,000 population) and number of cases (1.9 [range 1.3–2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164–1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed. KW - bacteremia KW - Salmonella KW - incidence KW - global burden KW - invasive disease KW - nontyphoidal Salmonella disease KW - bacteria DO - 10.3201/eid2106.140999 UR - https://wwwnc.cdc.gov/eid/article/21/6/14-0999_article ER - End of Reference