TY - JOUR AU - Pesesky, Mitchell AU - Hussain, Tahir AU - Wallace, Meghan AU - Wang, Bin AU - Andleeb, Saadia AU - Burnham, Carey-Ann AU - Dantas, Gautam T1 - KPC and NDM-1 Genes in Related Enterobacteriaceae Strains and Plasmids from Pakistan and the United States T2 - Emerging Infectious Disease journal PY - 2015 VL - 21 IS - 6 SP - 1034 SN - 1080-6059 AB - To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase. High similarities of the results indicate rapid spread of carbapenem resistance between strains, including globally disseminated pathogens. KW - Carbapenems KW - antimicrobial resistance KW - Enterobacter KW - Enterobacteriaceae KW - Escherichia coli KW - gene transfer KW - genomics KW - Klebsiella infections KW - Klebsiella pneumonia KW - bacteria KW - multilocus sequence typing KW - phylogeny KW - plasmids KW - transposases KW - United States KW - Pakistan KW - antibiotic drugs KW - beta-Lactam resistance KW - beta-Lactamases KW - beta-Lactams KW - next-generation sequencing DO - 10.3201/eid2106.141504 UR - https://wwwnc.cdc.gov/eid/article/21/6/14-1504_article ER - End of Reference