TY - JOUR AU - Fitzgerald, Felicity AU - Naveed, Asad AU - Wing, Kevin AU - Gbessay, Musa AU - Ross, J.C.G. AU - Checchi, Francesco AU - Youkee, Daniel AU - Jalloh, Mohammed Boie AU - Baion, David AU - Mustapha, Ayeshatu AU - Jah, Hawanatu AU - Lako, Sandra AU - Oza, Shefali AU - Boufkhed, Sabah AU - Feury, Reynold AU - Bielicki, Julia AU - Gibb, Diana AU - Klein, Nigel AU - Sahr, Foday AU - Yeung, Shunmay T1 - Ebola Virus Disease in Children, Sierra Leone, 2014–2015 T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 10 SP - 1769 SN - 1080-6059 AB - Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014–2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus–positive children 2 days–12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children. KW - Ebola virus disease KW - children KW - Ebola KW - Sierra Leone KW - viruses DO - 10.3201/eid2210.160579 UR - https://wwwnc.cdc.gov/eid/article/22/10/16-0579_article ER - End of Reference