TY - JOUR AU - Leeyaphan, Charussri AU - Ong, Jason AU - Chow, Eric P.F. AU - Kong, Fabian Y.S. AU - Hocking, Jane AU - Bissessor, Melanie AU - Fairley, Christopher AU - Chen, Marcus T1 - Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 10 SP - 1778 SN - 1080-6059 AB - Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I2 = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM. KW - rectal lymphogranuloma venereum KW - treatment KW - chlamydia KW - Chlamydia trachomatis KW - doxycycline KW - men who have sex with men KW - systematic review KW - metaanalysis KW - efficacy KW - sexually transmitted infection KW - STI KW - bacteria KW - meta-analysis DO - 10.3201/eid2210.160986 UR - https://wwwnc.cdc.gov/eid/article/22/10/16-0986_article ER - End of Reference