TY - JOUR AU - Aliabadi, Negar AU - Messacar, Kevin AU - Pastula, Daniel AU - Robinson, Christine AU - Leshem, Eyal AU - Sejvar, James AU - Nix, W. Allan AU - Oberste, M. Steven AU - Feikin, Daniel AU - Dominguez, Samuel T1 - Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014 T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 8 SP - 1387 SN - 1080-6059 AB - During August 8, 2014–October 14, 2014, a total of 11 children with acute flaccid myelitis and distinctive neuroimaging changes were identified near Denver, Colorado, USA. A respiratory prodrome was experienced by 10, and nasopharyngeal specimens were positive for enterovirus D68 (EV-D68) for 4. To determine whether an association exists between EV-D68 infection and acute flaccid myelitis, we conducted a retrospective case–control study comparing these patients with 2 groups of outpatient control children (1 group tested for acute respiratory illness and 1 for Bordetella pertussis infection). Adjusted analyses indicated that, for children with acute flaccid myelitis, the odds of having EV-D68 infection were 10.3 times greater than for those tested for acute respiratory infection and 4.5 times greater than for those tested for B. pertussis infection. No statistical association was seen between acute flaccid myelitis and non–EV-D68 enterovirus or rhinovirus infection. These findings support an association between EV-D68 infection and acute flaccid myelitis. KW - myelitis KW - enterovirus infections KW - enterovirus-D68 KW - acute flaccid paralysis KW - viruses KW - children KW - Colorado KW - acute flaccid myelitis KW - United States DO - 10.3201/eid2208.151949 UR - https://wwwnc.cdc.gov/eid/article/22/8/15-1949_article ER - End of Reference