TY - JOUR AU - Shirreff, George AU - Wadood, Mufti Zubair AU - Vaz, Rui Gama AU - Sutter, Roland AU - Grassly, Nicholas T1 - Estimated Effect of Inactivated Poliovirus Vaccine Campaigns, Nigeria and Pakistan, January 2014–April 2016 T2 - Emerging Infectious Disease journal PY - 2017 VL - 23 IS - 2 SP - 258 SN - 1080-6059 AB - In 2014, inactivated poliovirus vaccine (IPV) campaigns were implemented in Nigeria and Pakistan after clinical trials showed that IPV boosts intestinal immunity in children previously given oral poliovirus vaccine (OPV). We estimated the effect of these campaigns by using surveillance data collected during January 2014–April 2016. In Nigeria, campaigns with IPV and trivalent OPV (tOPV) substantially reduced the incidence of poliomyelitis caused by circulating serotype-2 vaccine–derived poliovirus (incidence rate ratio [IRR] 0.17 for 90 days after vs. 90 days before campaigns, 95% CI 0.04–0.78) and the prevalence of virus in environmental samples (prevalence ratio [PR] 0.16, 95% CI 0.02–1.33). Campaigns with tOPV alone resulted in similar reductions (IRR 0.59, 95% CI 0.18–1.97; PR 0.45, 95% CI 0.21–0.95). In Pakistan, the effect of IPV+tOPV campaigns on wild-type poliovirus was not significant. Results suggest that administration of IPV alongside OPV can decrease poliovirus transmission if high vaccine coverage is achieved. KW - poliovirus KW - polio KW - vaccines KW - viruses KW - epidemiology KW - Nigeria KW - Pakistan KW - inactivated poliovirus vaccine KW - IPV KW - vaccine campaign KW - mass campaign KW - vaccination KW - immunization KW - trivalent oral polio vaccine DO - 10.3201/eid2302.161210 UR - https://wwwnc.cdc.gov/eid/article/23/2/16-1210_article ER - End of Reference