TY - JOUR
AU - Ben-Ami, Ronen
AU - Berman, Judith
AU - Novikov, Ana
AU - Bash, Edna
AU - Shachor-Meyouhas, Yael
AU - Zakin, Shiri
AU - Maor, Yasmin
AU - Tarabia, Jalal
AU - Schechner, Vered
AU - Adler, Amos
AU - Finn, Talya
T1 - Multidrug-Resistant Candida haemulonii and C. auris, Tel Aviv, Israel
T2 - Emerging Infectious Disease journal
PY - 2017
VL - 23
IS - 2
SP - 195
SN - 1080-6059
AB - Candida auris and C. haemulonii are closely related, multidrug-resistant emerging fungal pathogens that are not readily distinguishable with phenotypic assays. We studied C. auris and C. haemulonii clinical isolates from 2 hospitals in central Israel. C. auris was isolated in 5 patients with nosocomial bloodstream infection, and C. haemulonii was found as a colonizer of leg wounds at a peripheral vascular disease clinic. Liberal use of topical miconazole and close contact among patients were implicated in C. haemulonii transmission. C. auris exhibited higher thermotolerance, virulence in a mouse infection model, and ATP-dependent drug efflux activity than C. haemulonii. Comparison of ribosomal DNA sequences found that C. auris strains from Israel were phylogenetically distinct from isolates from East Asia, South Africa and Kuwait, whereas C. haemulonii strains from different countries were closely interrelated. Our findings highlight the pathogenicity of C. auris and underscore the need to limit its spread.
KW - Candida auris
KW - Candida haemulonii
KW - virulence
KW - bloodstream infection
KW - antimicrobial resistance
KW - Israel
KW - fungi
DO - 10.3201/eid2302.161486
UR - https://wwwnc.cdc.gov/eid/article/23/2/16-1486_article
ER - End of Reference