TY - JOUR AU - Roundy, Christopher AU - Azar, Sasha AU - Rossi, Shannan AU - Huang, Jing AU - Leal, Grace AU - Yun, Ruimei AU - Fernandez-Salas, Ildefonso AU - Vitek, Christopher AU - Paploski, Igor A.D. AU - Kitron, Uriel AU - Ribeiro, Guilherme AU - Hanley, Kathryn AU - Weaver, Scott AU - Vasilakis, Nikos T1 - Variation in Aedes aegypti Mosquito Competence for Zika Virus Transmission T2 - Emerging Infectious Disease journal PY - 2017 VL - 23 IS - 4 SP - 625 SN - 1080-6059 AB - To test whether Zika virus has adapted for more efficient transmission by Aedes aegypti mosquitoes, leading to recent urban outbreaks, we fed mosquitoes from Brazil, the Dominican Republic, and the United States artificial blood meals containing 1 of 3 Zika virus strains (Senegal, Cambodia, Mexico) and monitored infection, dissemination, and virus in saliva. Contrary to our hypothesis, Cambodia and Mexica strains were less infectious than the Senegal strain. Only mosquitoes from the Dominican Republic transmitted the Cambodia and Mexica strains. However, blood meals from viremic mice were more infectious than artificial blood meals of comparable doses; the Cambodia strain was not transmitted by mosquitoes from Brazil after artificial blood meals, whereas 61% transmission occurred after a murine blood meal (saliva titers up to 4 log10 infectious units/collection). Although regional origins of vector populations and virus strain influence transmission efficiency, Ae. aegypti mosquitoes appear to be competent vectors of Zika virus in several regions of the Americas. KW - Aedes aegypti KW - Zika KW - transmission KW - vector competence KW - vector-borne infections KW - viruses KW - arbovirus KW - flaviviruses KW - mosquitoes KW - Zika virus KW - United States KW - Brazil KW - Dominican Republic DO - 10.3201/eid2304.161484 UR - https://wwwnc.cdc.gov/eid/article/23/4/16-1484_article ER - End of Reference