TY - JOUR AU - Ochomo, Eric AU - Chahilu, Mercy AU - Cook, Jackie AU - Kinyari, Teresa AU - Bayoh, Nabie AU - West, Philippa AU - Kamau, Luna AU - Osangale, Aggrey AU - Ombok, Maurice AU - Njagi, Kiambo AU - Mathenge, Evan AU - Muthami, Lawrence AU - Subramaniam, Krishanthi AU - Knox, Tessa AU - Mnavaza, Abraham AU - Donnelly, Martin James AU - Kleinschmidt, Immo AU - Mbogo, Charles T1 - Insecticide-Treated Nets and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya T2 - Emerging Infectious Disease journal PY - 2017 VL - 23 IS - 5 SP - 758 SN - 1080-6059 AB - Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9–2.5) infections/person-year and 2.8 (95% CI 2.5–3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42–0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35–0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance. KW - malaria infection incidence KW - insecticide resistance KW - cohorts KW - malaria KW - parasites KW - Kenya KW - Africa KW - bed nets KW - insecticide-treated nets KW - vector-borne infections KW - permethrin KW - deltamethrin DO - 10.3201/eid2305.161315 UR - https://wwwnc.cdc.gov/eid/article/23/5/16-1315_article ER - End of Reference