TY - JOUR AU - Marrie, Thomas AU - Tyrrell, Gregory AU - Majumdar, Sumit AU - Eurich, Dean T1 - Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae T2 - Emerging Infectious Disease journal PY - 2017 VL - 23 IS - 7 SP - 1118 SN - 1080-6059 AB - Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. We captured sociodemographic and serologic data for adults with IPD in a population-based cohort study in northern Alberta, Canada, during 2000–2014. IPD patients infected with HCV were compared with IPD patients not infected with HCV for risk of in-hospital deaths and complications by using multivariable logistic regression. A total of 355 of 3,251 patients with IPD were co-infected with HCV. The in-hospital mortality rate was higher for IPD patients infected with HCV. Prevalence of most IPD-related complications (e.g., cellulitis, acute kidney injury, mechanical ventilation) was also higher in HCV-infected patients. Infection with HCV is common in patients with IPD, and HCV is independently associated with an increased risk for serious illness and death. KW - hepatitis C KW - hepatitis C virus KW - HCV KW - viruses KW - Streptococcus pneumoniae KW - bacteria KW - streptococci KW - invasive pneumococcal disease (IPD) KW - respiratory infections KW - prevalence KW - correlates KW - outcomes KW - concurrent infection KW - mortality rates KW - complications KW - serotypes KW - Alberta KW - Canada KW - invasive pneumococcal disease KW - IPD KW - co-infection DO - 10.3201/eid2307.161858 UR - https://wwwnc.cdc.gov/eid/article/23/7/16-1858_article ER - End of Reference