TY - JOUR AU - Tai, Alex Y.C. AU - Athan, Eugene AU - Friedman, N. Deborah AU - Hughes, Andrew AU - Walton, Aaron AU - O’Brien, Daniel T1 - Increased Severity and Spread of Mycobacterium ulcerans, Southeastern Australia T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 1 SP - 58 SN - 1080-6059 AB - Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in southeastern Australia and spreading into new geographic areas. We analyzed 426 cases of M. ulcerans disease during January 1998–May 2017 in the established disease-endemic region of the Bellarine Peninsula and the emerging endemic region of the Mornington Peninsula. A total of 20.4% of cases patients had severe disease. Over time, there has been an increase in the number of cases managed per year and the proportion associated with severe disease. Risk factors associated with severe disease included age, time period (range of years of diagnosis), and location of lesions over a joint. We highlight the changing epidemiology and pathogenicity of M. ulcerans disease in Australia. Further research, including genomic studies of emergent strains with increased pathogenicity, is urgently needed to improve the understanding of this disease to facilitate implementation of effective public health measures to halt its spread. KW - Mycobacteria ulcerans KW - bacteria KW - Mycobacteria ulcerans disease KW - Buruli ulcer KW - severity KW - spread KW - severe disease KW - tuberculosis and other mycobacteria KW - zoonoses KW - Australia DO - 10.3201/eid2401.171070 UR - https://wwwnc.cdc.gov/eid/article/24/1/17-1070_article ER - End of Reference