TY - JOUR AU - Gordon, Aubree AU - Tsang, Tim AU - Cowling, Benjamin AU - Kuan, Guillermina AU - Ojeda, Sergio AU - Sanchez, Nery AU - Gresh, Lionel AU - Lopez, Roger AU - Balmaseda, Angel AU - Harris, Eva T1 - Influenza Transmission Dynamics in Urban Households, Managua, Nicaragua, 2012–2014 T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 10 SP - 1882 SN - 1080-6059 AB - During August 2012–November 2014, we conducted a case ascertainment study to investigate household transmission of influenza virus in Managua, Nicaragua. We collected up to 5 respiratory swab samples from each of 536 household contacts of 133 influenza virus–infected persons and assessed for evidence of influenza virus transmission. The overall risk for influenza virus infection of household contacts was 15.7% (95% CI 12.7%–19.0%). Oseltamivir treatment of index patients did not appear to reduce household transmission. The mean serial interval for within-household transmission was 3.1 (95% CI 1.6–8.4) days. We found the transmissibility of influenza B virus to be higher than that of influenza A virus among children. Compared with households with <4 household contacts, those with >4 household contacts appeared to have a reduced risk for infection. Further research is needed to model household influenza virus transmission and design interventions for these settings. KW - household KW - influenza KW - Nicaragua KW - serial interval KW - transmission KW - viruses KW - respiratory infections KW - influenza A KW - influenza B KW - Managua KW - H1N1 KW - H3N2 KW - risk for infection KW - household transmission KW - oseltamivir KW - age KW - household contacts KW - vaccination DO - 10.3201/eid2410.161258 UR - https://wwwnc.cdc.gov/eid/article/24/10/16-1258_article ER - End of Reference