TY - JOUR AU - Kaarme, Johan AU - Riedel, Hilde AU - Schaal, Wesley AU - Yin, Hong AU - Nevéus, Tryggve AU - Melhus, Åsa T1 - Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 10 SP - 1874 SN - 1080-6059 AB - By collecting and analyzing diapers, we identified a >6-fold increase in carriage of extended-spectrum β-lactamase (ESBL)–producing Enterobacteriaceae for healthy preschool children in Sweden (p<0.0001). For 6 of the 50 participating preschools, the carriage rate was >40%. We analyzed samples from 334 children and found 56 containing >1 ESBL producer. The prevalence in the study population increased from 2.6% in 2010 to 16.8% in 2016 (p<0.0001), and for 6 of the 50 participating preschools, the carriage rate was >40%. Furthermore, 58% of the ESBL producers were multidrug resistant, and transmission of ESBL-producing and non–ESBL-producing strains was observed at several of the preschools. Toddlers appear to be major carriers of ESBL producers in Sweden. KW - carriage rates KW - Enterobacteriaceae KW - bacteria KW - extended-spectrum β-lactamases KW - ESBLs KW - healthy preschool children KW - AmpC KW - preschool children KW - cephalosporin-resistance KW - antimicrobial resistance KW - Sweden KW - cephalosporin resistance KW - whole-genome sequencing KW - enteric infections KW - respiratory infections DO - 10.3201/eid2410.171842 UR - https://wwwnc.cdc.gov/eid/article/24/10/17-1842_article ER - End of Reference