TY - JOUR AU - Subissi, Lorenzo AU - Dub, Timothée AU - Besnard, Marianne AU - Mariteragi-Helle, Teheipuaura AU - Nhan, Tuxuan AU - Lutringer-Magnin, Delphine AU - Barboza, Philippe AU - Gurry, Céline AU - Brindel, Pauline AU - Nilles, Eric AU - Baud, David AU - Merianos, Angela AU - Musso, Didier AU - Glynn, Judith AU - Dupuis, Gilles AU - Cao-Lormeau, Van-Mai AU - Giard, Marine AU - Mallet, Henri-Pierre T1 - Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013–2016 T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 10 SP - 1850 SN - 1080-6059 AB - Congenital Zika virus syndrome consists of a large spectrum of neurologic abnormalities seen in infants infected with Zika virus in utero. However, little is known about the effects of Zika virus intrauterine infection on the neurocognitive development of children born without birth defects. Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. In a nested study, we also assessed the early childhood development of children recruited in the initial study as controls who were born without known birth defects,. We found evidence for an association of congenital defects with both maternal Zika virus seropositivity (time of infection unknown) and symptomatic Zika virus infection during pregnancy. Although the early childhood development assessment found no excess burden of developmental delay associated with maternal Zika virus infection, larger, longer-term studies are needed. KW - Zika virus infection KW - Pacific Islands KW - French Polynesia KW - congenital Zika syndrome KW - child health KW - viruses KW - early childhood development DO - 10.3201/eid2410.172079 UR - https://wwwnc.cdc.gov/eid/article/24/10/17-2079_article ER - End of Reference