TY - JOUR AU - Huang, Jiao AU - Liao, Qiaohong AU - Ooi, Mong How AU - Cowling, Benjamin AU - Chang, Zhaorui AU - Wu, Peng AU - Liu, Fengfeng AU - Li, Yu AU - Luo, Li AU - Yu, Shuanbao AU - Yu, Hongjie AU - Wei, Sheng T1 - Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008–2015 T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 3 SP - 432 SN - 1080-6059 AB - Using China’s national surveillance data on hand, foot and mouth disease (HFMD) for 2008–2015, we described the epidemiologic and virologic features of recurrent HFMD. A total of 398,010 patients had HFMD recurrence; 1,767 patients had 1,814 cases of recurrent laboratory-confirmed HFMD: 99 reinfections of enterovirus A71 (EV-A71) with EV-A71, 45 of coxsackievirus A16 (CV-A16) with CV-A16, 364 of other enteroviruses with other enteroviruses, 383 of EV-A71 with CV-A16 and CV-A16 with EV-A71, and 923 of EV-A71 or CV-A16 with other enteroviruses and other enteroviruses with EV-A71 or CV-A16. The probability of HFMD recurrence was 1.9% at 12 months, 3.3% at 24 months, 3.9% at 36 months, and 4.0% at 38.8 months after the primary episode. HFMD severity was not associated with recurrent episodes or time interval between episodes. Elucidation of the mechanism underlying HFMD recurrence with the same enterovirus serotype and confirmation that HFMD recurrence is not associated with disease severity is needed. KW - hand foot and mouth disease KW - recurrence KW - reinfection KW - viruses KW - China KW - respiratory infection KW - enterovirus A71 KW - coxsackie virus A16 KW - enteroviruses KW - coxsackievirus A16 KW - EV-A71 KW - CV-A16 KW - epidemiology DO - 10.3201/eid2403.171303 UR - https://wwwnc.cdc.gov/eid/article/24/3/17-1303_article ER - End of Reference