TY - JOUR AU - O’Connell, Elise AU - Mitchell, Tarissa AU - Papaiakovou, Marina AU - Pilotte, Nils AU - Lee, Deborah AU - Weinberg, Michelle AU - Sakulrak, Potsawin AU - Tongsukh, Dilok AU - Oduro-Boateng, Georgiette AU - Harrison, Sarah AU - Williams, Steven AU - Stauffer, William AU - Nutman, Thomas T1 - Ancylostoma ceylanicum Hookworm in Myanmar Refugees, Thailand, 2012–2015 T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 8 SP - 1472 SN - 1080-6059 AB - During 2012–2015, US-bound refugees living in Myanmar–Thailand border camps (n = 1,839) were surveyed for hookworm infection and treatment response by using quantitative PCR. Samples were collected at 3 time points: after each of 2 treatments with albendazole and after resettlement in the United States. Baseline prevalence of Necator americanus hookworm was 25.4%, Ancylostoma duodenale 0%, and Ancylostoma ceylanicum (a zoonosis) 5.4%. Compared with N. americanus prevalence, A. ceylanicum hookworm prevalence peaked in younger age groups, and blood eosinophil concentrations during A. ceylanicum infection were higher than those for N. americanus infection. Female sex was associated with a lower risk for either hookworm infection. Cure rates after 1 dose of albendazole were greater for A. ceylanicum (93.3%) than N. americanus (65.9%) hookworm (p<0.001). Lower N. americanus hookworm cure rates were unrelated to β-tubulin single-nucleotide polymorphisms at codons 200 or 167. A. ceylanicum hookworm infection might be more common in humans than previously recognized. KW - hookworm KW - Ancylostoma KW - Ancylostoma ceylanicum KW - Ancylostoma duodenale KW - Necator americanus KW - soil-transmitted helminths KW - refugees KW - Myanmar KW - Thailand KW - Burmese KW - parasites KW - albendazole KW - β-tubulin SNP KW - CME KW - neglected tropical disease KW - benzimidazole KW - United States KW - SNP200 KW - SNP167 KW - zoonoses KW - eosinophils KW - hemoglobin KW - cure rate DO - 10.3201/eid2408.180280 UR - https://wwwnc.cdc.gov/eid/article/24/8/18-0280_article ER - End of Reference