TY - JOUR AU - Ergönül, Önder AU - Keske, Şiran AU - Çeldir, Melis Gökçe AU - Kara, İlayda Arjen AU - Pshenichnaya, Natalia AU - Abuova, Gulzhan AU - Blumberg, Lucille AU - Gönen, Mehmet T1 - Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 9 SP - 1642 SN - 1080-6059 AB - We performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood or bodily fluids (odds ratio [OR] 4.2), being a nurse or physician (OR 2.1), and treating patients who died from CCHFV infection (OR 3.8) were associated with healthcare workers acquiring CCHFV infection; 7% of the workers who received postexposure prophylaxis (PEP) with ribavirin and 89% of those who did not became infected. PEP with ribavirin reduced the odds of infection (OR 0.01, 95% CI 0–0.03), and ribavirin use <48 hours after symptom onset reduced the odds of death (OR 0.03, 95% CI 0–0.58). The odds of death increased 2.4-fold every day without ribavirin treatment. Ribavirin should be recommended as PEP and early treatment for workers at medium-to-high risk for CCHFV infection. KW - Crimean-Congo hemorrhagic fever KW - ribavirin KW - healthcare workers KW - post-exposure prophylaxis KW - early treatment KW - CCHF KW - viral hemorrhagic fever KW - PRISMA KW - meta-analysis KW - viruses KW - vector-borne infection KW - zoonoses KW - systematic review KW - postexposure prophylaxis KW - vector-borne infections KW - Crimean-Congo hemorrhagic fever virus KW - CCHFV KW - Turkey KW - Pakistan KW - Germany KW - Iran KW - India KW - South Africa KW - Russia KW - Tajikistan KW - Arabic Emirates KW - Mauritania KW - Kazakhstan KW - Sudan KW - Albania KW - and Spain DO - 10.3201/eid2409.171709 UR - https://wwwnc.cdc.gov/eid/article/24/9/17-1709_article ER - End of Reference