TY - JOUR
AU - Delamater, Paul
AU - Street, Erica
AU - Leslie, Timothy
AU - Yang, Y. Tony
AU - Jacobsen, Kathryn
T1 - Complexity of the Basic Reproduction Number (R_{0})
T2 - Emerging Infectious Disease journal
PY - 2019
VL - 25
IS - 1
SP - 1
SN - 1080-6059
AB - The basic reproduction number (R0), also called the basic reproduction ratio or rate or the basic reproductive rate, is an epidemiologic metric used to describe the contagiousness or transmissibility of infectious agents. R0 is affected by numerous biological, sociobehavioral, and environmental factors that govern pathogen transmission and, therefore, is usually estimated with various types of complex mathematical models, which make R0 easily misrepresented, misinterpreted, and misapplied. R0 is not a biological constant for a pathogen, a rate over time, or a measure of disease severity, and R0 cannot be modified through vaccination campaigns. R0 is rarely measured directly, and modeled R0 values are dependent on model structures and assumptions. Some R0 values reported in the scientific literature are likely obsolete. R0 must be estimated, reported, and applied with great caution because this basic metric is far from simple.
KW - basic reproduction number
KW - theoretical models
KW - disease outbreaks
KW - infectious disease transmission
KW - R0
KW - mathematical modeling
KW - outbreaks
KW - basic reproductive ratio
KW - basic reproductive rate
KW - basic reproduction ratio
KW - basic reproduction rate
DO - 10.3201/eid2501.171901
UR - https://wwwnc.cdc.gov/eid/article/25/1/17-1901_article
ER - End of Reference