TY - JOUR AU - Delamater, Paul AU - Street, Erica AU - Leslie, Timothy AU - Yang, Y. Tony AU - Jacobsen, Kathryn T1 - Complexity of the Basic Reproduction Number (R0) T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 1 SP - 1 SN - 1080-6059 AB - The basic reproduction number (R0), also called the basic reproduction ratio or rate or the basic reproductive rate, is an epidemiologic metric used to describe the contagiousness or transmissibility of infectious agents. R0 is affected by numerous biological, sociobehavioral, and environmental factors that govern pathogen transmission and, therefore, is usually estimated with various types of complex mathematical models, which make R0 easily misrepresented, misinterpreted, and misapplied. R0 is not a biological constant for a pathogen, a rate over time, or a measure of disease severity, and R0 cannot be modified through vaccination campaigns. R0 is rarely measured directly, and modeled R0 values are dependent on model structures and assumptions. Some R0 values reported in the scientific literature are likely obsolete. R0 must be estimated, reported, and applied with great caution because this basic metric is far from simple. KW - basic reproduction number KW - theoretical models KW - disease outbreaks KW - infectious disease transmission KW - R0 KW - mathematical modeling KW - outbreaks KW - basic reproductive ratio KW - basic reproductive rate KW - basic reproduction ratio KW - basic reproduction rate DO - 10.3201/eid2501.171901 UR - https://wwwnc.cdc.gov/eid/article/25/1/17-1901_article ER - End of Reference