TY - JOUR AU - Van Kerkhove, Maria AU - Alaswad, Sadoof AU - Assiri, Abdullah AU - Perera, Ranawaka A.P.M. AU - Peiris, Malik AU - El Bushra, Hassan AU - BinSaeed, Abdulaziz T1 - Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015 T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 10 SP - 1802 SN - 1080-6059 AB - To investigate a cluster of Middle East respiratory syndrome (MERS) cases in a women-only dormitory in Riyadh, Saudi Arabia, in October 2015, we collected epidemiologic information, nasopharyngeal/oropharyngeal swab samples, and blood samples from 828 residents during November 2015 and December 2015–January 2016. We found confirmed infection for 19 (8 by reverse transcription PCR and 11 by serologic testing). Infection attack rates varied (2.7%–32.3%) by dormitory building. No deaths occurred. Independent risk factors for infection were direct contact with a confirmed case-patient and sharing a room with a confirmed case-patient; a protective factor was having an air conditioner in the bedroom. For 9 women from whom a second serum sample was collected, antibodies remained detectable at titers >1:20 by pseudoparticle neutralization tests (n = 8) and 90% plaque-reduction neutralization tests (n = 2). In closed high-contact settings, MERS coronavirus was highly infectious and pathogenicity was relatively low. KW - MERS-CoV KW - Middle East respiratory syndrome coronavirus KW - human-to-human transmission KW - seroepidemiology KW - outbreak investigation KW - viruses KW - Riyadh KW - Saudi Arabia DO - 10.3201/eid2510.190130 UR - https://wwwnc.cdc.gov/eid/article/25/10/19-0130_article ER - End of Reference