TY - JOUR AU - Otsuji, Ken AU - Fukuda, Kazumasa AU - Ogawa, Midori AU - Saito, Mitsumasa T1 - Mutation and Diversity of Diphtheria Toxin in Corynebacterium ulcerans T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 11 SP - 2122 SN - 1080-6059 AB - Corynebacterium ulcerans infection is emerging in humans. We conducted phylogenetic analyses of C. ulcerans and C. diptheriae, which revealed diverse diphtheria toxin in C. ulcerans. Diphtheria toxin diversification could decrease effectiveness of diphtheria toxoid vaccine and diphtheria antitoxin for preventing and treating illnesses caused by this bacterium. KW - Diphtheria toxin KW - Corynebacterium ulcerans KW - diversity KW - amino acid sequence KW - bacteria KW - Japan DO - 10.3201/eid2511.181455 UR - https://wwwnc.cdc.gov/eid/article/25/11/18-1455_article ER - End of Reference